Since the rise of stem cell research, human embryonic stem cells (hESC for short) have received extensive attention because of their ability to express human biological characteristics and have high clinical application value. With the continuous attempts of scientists, human embryonic stem cells can be differentiated into A variety of cells, such as neurons, cardiomyocytes, islet cells, and blood cells.
At the beginning of the New Year 2013, "Nature" mouse ELISA kit magazine looked forward to some important discoveries and major events that may appear this year. One of the early clinical trials using human embryonic stem cells (hESC) is particularly worthy of attention, Santa California, USA A biotechnology company "Advanced Cell Technology" in Monica City is injecting hESC-derived retinal cells into the eyes of 36 patients with two forms of incurable degenerative blindness. In February this year, Heriot-Watt, United Kingdom The university has collaborated with a stem cell technology company to develop a valve-based three-dimensional (3D) printing technology, expanding 3D printing to the range of human embryonic stem cells for the first time. Relevant research on human embryonic stem cells is developing rapidly. The author summarizes some important research progress on human embryonic stem cells in the past year as follows.
Using human embryonic stem cells is expected to restore vision
According to a new study, human stem cells can spontaneously form a mouse ELISA kit tissue, which can produce the part of the eye that allows us to see things. Related research results were published on June 14, 2012 Cell Stem Cell Journal. In the future, transplanting this three-dimensional tissue may help patients with impaired vision to see things clearly. During development, the photosensitive tissue located behind the eye is called the retina, forming a type called the visual The structure of the optical cup. In this new study, thanks to Sasai and his research team optimizing the cell culture method, this structure can be spontaneously produced by human embryonic stem cells. Corresponding author of the paper, Japan Institute of Physics and Chemistry Yoshiki Sasai, a researcher at the Biology Center, said, "This study opens the door to understanding human-specific eye developmental characteristics, because researchers were not able to study these developmental characteristics until then."
Using embryonic stem cells to repair memory in mice
On April 21, 2013, "Nature Biotechnol" published a study by Su-Chun Zhang, a professor of neuroscience and neuroscience at Wisconsin-Madison University, which proved for the first time that human embryonic stem cells can be transformed into nerve cells, helping mice regain their learning and memory abilities .Human stem cells can be successfully implanted in their own brain to treat neurological deficits.
Using human embryonic stem cells can successfully differentiate into bone cells
Researchers at the New York Stem Cell Research Center (NYSCF) said that human embryonic stem cells can differentiate into bone tissue for transplantation studies and potential treatments.This study was published in the international journal PNAS on May 14, 2012. In the article, the researchers used osteoblast progenitor cells derived from embryonic stem cells for the first time to generate compact bone tissue to repair centimeter-sized defects.
The first use of embryonic stem cells to regenerate thyroid tissue
On October 12, 2012, with the help of American colleagues, Swiss researchers successfully used mouse embryonic stem cells to successfully create thyroid tissue. They also found that this newly generated tissue was transplanted to 10 The dysfunction of the thyroid gland of the experimental mice can completely restore the thyroid function of 9 of them. The relevant research results were published in the journal Nature in October 2012.
Human embryonic stem cells can be induced into sperm precursor cells
Researchers at the University of Pittsburgh School of Medicine confirmed that human embryonic stem cells and human induced pluripotent stem cells (iPS cells) can be induced into sperm precursor cells, suggesting that it may be used to restore fertility in infertile men in the future. Will be published in Cell Reports magazine.
Using human embryonic stem cells to efficiently manufacture therapeutic vaccines against cancer
In September 2012, a study carried out by the Singapore Institute of Bioengineering and Nanotechnology of the mouse ELISA kit used human embryonic stem cells (embryonic stem cells) to generate dendritic cells (DC) to stimulate the immune system to fight tumors. May be a more economical way to generate therapeutic vaccines against cancer.
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