The research team of Wang Jiyang, Department of Immunology, School of Basic Medical Sciences, Fudan University, discovered the receptor for immunoglobulin IgM in the latest research. Immunoglobulin IgM is known as the body's "first line of defense" against viral and bacterial infections. When IgM is combined with the receptor, it can not only promote the body's immune function, but also inhibit its own "harmful" antibody production. This research is of great significance for the treatment of human immunodeficiency and autoimmune diseases. Related results were published online in the Proceedings of the National Academy of Sciences.
It is understood that immunoglobulin IgM is the earliest antibody in the initial immune response. After IgM antibody directly binds to the pathogen, it can inhibit the activity of the pathogen, prevent its onset and development, and can dissolve the pathogen through a special way to prevent the expansion of the infection. As early as 40 years ago, scientists around the world discovered that there is an IgM receptor on the surface of B lymphocytes, and there is evidence to support this inference, but it has not been found.
Wang Jiyang's group used gene knockout technology to successfully breed a knockout mouse lacking the "FcμR gene", and analyzed the immune function and autoantibodies that this mouse would produce in the absence of the gene. result. After three years of hard work, they finally discovered the receptor gene FcμR for the first time.
The study found that when foreign pathogens invaded the FcμR gene-knockout mice, there was an obvious immunodeficiency, and their antibodies dropped to less than 1/3 of normal mice. Further studies have shown that this immunodeficiency is due to the fact that after the FcμR gene is knocked out, B lymphocytes are not easy to be activated after being stimulated by foreign pathogens, but also cause death. In contrast, knockout mice lacking the FcμR gene will produce a large amount of harmful autoantibodies without any stimulation, including antinuclear antibodies and anti-DNA antibodies that may produce harmful systemic lupus erythematosus or classes that induce arthritis Rheumatic factors, etc.
Relevant experts said that in the future, IgM receptors on the surface of B lymphocytes can be activated to promote the production of beneficial antibodies in the body to enhance human immunity, or inhibitory antibodies can be used to treat various immunity caused by abnormal activation of B lymphocytes. Sexual diseases.
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