Carbon dioxide (CO2) is both a major greenhouse gas and a valuable carbon resource. The creation of new biosynthetic pathways and the use of solar energy to efficiently convert CO2 into petroleum-based chemicals will open up a new path for solving global resource and energy problems and have great significance for the sustainable development of industry.
Acetone is an important organic solvent and industrial raw material, and is one of the representative low-value, bulk petrochemical products. China's annual consumption of acetone exceeds 1.1 million tons, of which more than half depends on imports. Natural cyanobacteria can rapidly reproduce by fixing CO2 through photosynthesis, but due to the lack of acetone biosynthetic pathways, acetone cannot be synthesized.
Researcher Li Yin and Dr. Zhou Jie of the Institute of Microbiology of the Chinese Academy of Sciences first designed a metabolic pathway for biosynthesis of acetone from CO2, and then optimized and redistributed the carbon flow of the cyanobacteria endogenous photosynthetic carbon fixation module. The transacetylation module and the decarboxylation module related to acetone biosynthesis have effectively connected the cyanobacteria endogenous carbon fixation module and the two exogenous modules, extended the carbon flow to acetone, and created a new way to synthesize acetone from CO2.
As the first example of CO2 biosynthesis of ketones, the design ideas of the new approach in this work, as well as the method of module assembly and optimization, can also provide a reference for the use of CO2 biosynthesis of more bulk petrochemical products.
The work was published online in Metabolic Engineering magazine on March 28. The research was funded by the 973 project's major scientific problem-oriented project "Synthetic Cell Factory".
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