If the cancer stem cells are not completely eliminated in the treatment of cancer, the cancer can easily relapse and metastasize. Researchers at Kyoto University in Japan say they have found a marker protein contained in cancer stem cells, which is expected to "cut the grass".
The research team led by Professor Chiba Mian of the Department of Gastroenterology at Kyoto University noticed a protein Dclk1 in the digestive tract during the study. They analyzed the experimental mice suffering from colorectal cancer and found that the cells containing this protein will continue for a longer period of time. Produce cancer cells. They successfully eliminated cells containing Dclk1 protein through genetic manipulation. The area of ​​colorectal cancer tissue in the experimental mice was reduced by more than 80%, and some even disappeared completely, and no side effects were found.
If the cancer stem cells are not completely eliminated for cancer treatment, the cancer can easily recur and metastasize. Therefore, it is necessary to find the cancer stem cells and "cut the grass". However, some of the markers contained in cancer stem cells have been found in normal stem cells at the same time. If these substances are used to clear cancer stem cells, normal stem cells will be injured by mistake, causing side effects.
The researchers said that this is the first time that a marker substance that exists only in cancer stem cells has been found. With this substance as a target, a precise attack on cancer stem cells can be achieved. In addition, Dclk1 protein may also be a marker protein for pancreatic cancer, gastric cancer and other cancers.
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